Gastric Slow Wave and Autonomic Nervous Function in Cirrhotic Patients With Esophageal Varices After Ligation-A Clinical Research

Nanjing Medical University

Status: Completed

Conditions: Esophageal Varices in Cirrhosis of the Liver

Treatments: Diagnostic Test: Electrogastrogram(EGG); Diagnostic Test: Heart Rate Variability(HRV)

Study type: Observational

Funder types: Other

Identifiers

NCT04125875

2019-SR-086

Details and patient eligibility

About

This study is intended to include 20 patients with esophageal varices caused by liver cirrhosis who were admitted to the first affiliated hospital of nanjing medical university from May 2019, and randomly select 8 patients with gastric polyps as the control group.General clinical data, imaging data, endoscopic data and laboratory indicators were collected.Electrogastrogram (EGG) and Heart Rate Variability (HRV) were performed before and 24 hours after operation in patients with cirrhotic esophageal varices, and the dyspepsia scale was filled out.Electrogastrogram (EGG) and cardiac variability (HRV) were performed in patients with gastric polyps 24 hours before and after surgery, and the dyspepsia scale was filled.EGG uses the surface electrode to record gastric myoelectric activity, and evaluates the patient's gastric rhythm by normal slow wave ratio, overspeed ratio, overslow ratio, and rhythm disorder ratio.The HRV evaluates the balance state of the patient's autonomic nervous system with High Frequency (HF)/Low Frequency (LF).SPSS software was used for paired sample analysis of experimental results.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18 years old with cirrhosis of esophageal varices who underwent endoscopic ligation
• Signed informed consent

Exclusion criteria

• Hemorrhage in the digestive tract, unstable vital signs
• Hepatic encephalopathy
• Unwilling to cooperate with the examiner
• Skin allergies

Trial design

28 participants in 2 patient groups

Patients with cirrhosis of esophageal varices

Treatment:

Diagnostic Test: Heart Rate Variability(HRV)

Diagnostic Test: Electrogastrogram(EGG)

Patients with gastric polyps

Treatment:

Diagnostic Test: Heart Rate Variability(HRV)

Diagnostic Test: Electrogastrogram(EGG)