Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion

Brain-Gut Research Group

Status: Unknown

Conditions: Dental Erosion; Gastroesophageal Reflux

Study type: Observational

Funder types: Other

Identifiers

NCT02087345

BGRG-2414b

Details and patient eligibility

About

Dental erosions, the chemical dissolution of enamel without bacterial involvement, are considered to be an established complication of gastroesophageal reflux disease (GERD) by the Montreal global consensus statement. Given the high prevalence of dental erosions and the absence of any pH-impedance data or medical management guidelines for GERD-associated dental erosions, reflux characteristics will be characterized using questionnaires, endoscopy and esophageal pH-impedance testing, in successive patients dental erosions referred by dentists for evaluation of GERD. For assessment of the role of additional factors besides H+ activity in the refluxate, a sample of gastric juice will be aspirated during endoscopy and frozen for analysis of pepsin and other proteases. Prognostic factors for progression of dental erosions will be determined by repeating the evaluation after chronic dosing with esomeprazole 20mg twice-daily, which is prescribed to all patients.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Successive male and female patients
• Over 18 years of age presenting to the University of Bern Department of Dentistry and affiliated dentists
• Dental erosions

Exclusion criteria

• Non-reflux causes of erosion
• Reduced salivary flow and buffering capacity
• History of bruxism, eating disorders, recurrent vomiting, severe obesity (BMI>35kg/m2) or past bariatric surgery
• Dietary or abrasive causes for dental erosion

Trial design

500 participants in 1 patient group

Dental erosions