Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass

Clinica Gastrobese

Status: Completed

Conditions: Gastroesophageal Reflux Disease; Morbid Obesity

Treatments: Procedure: Gastric bypass

Study type: Observational

Funder types: Other

Identifiers

NCT00951093

GASTROBESE-004

Details and patient eligibility

About

The hypothesis of this study was that gastric bypass (GBP) ameliorates gastroesophageal reflux disease (GERD) in morbidly obese patients.

Full description

The investigators studied the impact of this surgical procedure on GERD in patients with morbid obesity.

Esophageal syndromes were evaluated according to the Montreal Consensus, where troublesome symptoms were defined as score ≥ 2 on a validated questionnaire of symptoms for Portuguese language along with esophageal syndromes with injury assessed through upper endoscopy.

Esophageal acid exposure was determined through 24h pH monitoring. Increased acid exposure was characterized when total esophageal pH < 4 for at least 4% of the total monitoring time.

Enrollment: 53 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Morbid obesity
• Acceptance to undergo open gastric bypass

Exclusion criteria

• Prior gastroesophageal surgery
• Achalasia

Trial design

53 participants in 1 patient group

Patients assessed for GERD

Description:

Patients who had an open gastric bypass were assessed for GERD before and after surgery following the Montreal Consensus through a validated questionnaire in Portuguese language

Treatment:

Procedure: Gastric bypass