GastroIntestinal Cancer in Children and Adolescents (GICCA)

Paul G. Kemps, MD

Status

Active, not recruiting

Conditions

Gastric Cancer

Gastrointestinal Cancer

Neuroendocrine Tumors

Hepatocellular Carcinoma

Hepatoblastoma

Burkitt Lymphoma

Colorectal Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT05693519

nWMO-D4-2022-031

Details and patient eligibility

About

The goal of this observational population-based cohort study is to investigate the clinical characteristics and outcomes of children and adolescents with primary gastrointestinal malignancies registered in the publicly available Surveillance, Epidemiology, and End Results (SEER) 17 database during 2000-2019.

Full description

The investigators aim to describe the patient and tumor characteristics, treatments, and outcomes of children and adolescents diagnosed with primary gastrointestinal malignancies, and to analyze these data for trends over time. In addition, the investigators want to explore independent prognostic factors for overall survival. Finally, the investigators want to describe subsequent primary malignancies diagnosed among patients from the study cohort, as well as to calculate their risk of developing a second primary cancer relative to the general population. Data on children (aged 0-17 years at diagnosis) and young people aged 18-24 years at diagnosis are analyzed separately. Special focus is laid on patients with primary carcinomas of the gastrointestinal tract; particularly colorectal carcinoma.

Enrollment

2,500 estimated patients

Sex

All

Ages

Under 24 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age at primary gastrointestinal cancer diagnosis <25 years
Diagnosis of a primary gastrointestinal malignancy as an individual's first primary malignancy

Exclusion criteria