Gastrointestinal Transit and Motility in Renal Transplant Recipients

Universidade Estadual de Ciências da Saúde de Alagoas

Status: Unknown

Conditions: Effects of Immunosuppressant Therapy; Change of Transit or Circulation

Study type: Observational

Funder types: Other

Identifiers

NCT01777204

FAPEAL-20110714-TX

Details and patient eligibility

About

Gastrointestinal (GI) complications after renal transplantation are commonly reported as side effects of immunosuppressive agents. Despite this, motility disorders have been scantily studied. Alternating Current Biosusceptometry (ACB) are biomagnetic sensors designed for a wide range of applications. In clinical practice, their non-invasive and radiation free features provide an excellent approach for monitoring of GI transit as alternative to scintigraphy and breath tests. The aim of this study is to examine GI transit and motility of solids in stable renal transplant recipients to determine the potential influence of immunosuppressive therapy on gastrointestinal parameters.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy Volunteer or Renal Transplant Patients
• Signed informed consent obtained
• Fasted since midnight

Exclusion criteria

• Subject has known GI related symptoms complaints or GI diseases
• Subject has cancer or other life threatening diseases or conditions
• Subject is pregnant
• Subject has undergone abdominal surgery
• Drug abuse or alcoholism
• Subject has cardiac pacemaker
• Subject takes any medication affecting GI motility

Trial design

20 participants in 7 patient groups

Tacrolimus

Description:

Influence of tacrolimus on gastrointestinal transit and motility in renal transplant recipients.

Cyclosporine

Description:

Influence of cyclosporine on gastrointestinal transit and motility in renal transplant recipients.

Mycophenolate mofetil

Description:

Influence of mycophenolate mofetil on gastrointestinal transit and motility in renal transplant recipients.

Mycophenolate sodium

Description:

Influence of mycophenolate sodium on gastrointestinal transit and motility in renal transplant recipients.

Everolimus

Description:

Influence of everolimus on gastrointestinal transit and motility in renal transplant recipients.

Sirolimus

Description:

influence of sirolimus on gastrointestinal transit and motility in renal transplant recipients.

Without immunosuppression

Description:

Gastrointestinal transit and motility in healthy volunteers.