GBR Versus Allogenic Bone Block

Algirdas Puisys, DDS, PhD

Status

Completed

Conditions

Implant Placement

Alveolar Bone Grafting

Treatments

Procedure: allogenic bone blocks

Procedure: allogenic cancellous bone granules

Study type

Interventional

Funder types

NETWORK

Identifiers

NCT07295041

BEC-LSMU(R)-51

Details and patient eligibility

About

This study aimed to compare two different methods used to augment bone in the posterior lower jaw prior to implant placement in patients with insufficient bone width. Eligible patients were included in the study and received a horizontal bone augmentation with one of two methods, which differed in the materials used for the bone augmentation. The group allocation was randomised. After 6 months of healing following parameters were assessed: histological evaluation, survival of the bone graft, the need for further bone augmentation at the time of implant placement, changes in soft tissue characteristics, radiologically and clinically assessed changes in bone width.

Full description

Objective: The objective of this study is to compare the histological, clinical, and radiographic outcomes of particulate bone substitutes versus allogenic bone block grafts for primary bone augmentation in the posterior mandible.

Materials and Methods: This randomised controlled clinical trial included adult patients in need for a staged bone augmentation prior to implant placement in the posterior mandible. Patients were randomly assigned to one of two treatments groups. Patients allocated in the BBL group received allogenic bone blocks, whereas patients in the GBR group received allogenic bone granules for the primary bone augmentation. In both groups grafting materials were covered with a resorbable collagen membrane, which was fixated with non-resorbable fixation pins. The primary outcome of this study was defined as the composition of the histological samples at least 6 months after the primary bone augmentation. Secondary outcomes included graft survival rates, the need for further augementation procedures at time of implant placement, soft tissue measurements and radiographically and clinically analyzed changes in bone width and radiographically analyzed changes in bone volume. These outcomes were measured at baseline (prior to bone augmentation surgery) and at the follow-up (at least 6 months after bone augmentation).

Enrollment

37 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged ≥18 years
Insufficient bone width in posterior mandible requiring staged bone augmentation prior to implant placement
Minimum of 1 mm bone width available
Willing to provide signed informed consent

Exclusion criteria

Pregnant or lactating
Known or suspected incompliance
Patients smoking more than 10 cigarettes per day
Systemic diseases or medications affecting bone metabolism (such as osteoporosis, intake of bisphosphonates)
Active periodontal disease