GCF Levels of Chemokines in Periodontitis

T.C. ORDU ÜNİVERSİTESİ

Status

Completed

Conditions

Periodontal Diseases

Treatments

Diagnostic Test: Routine periodontal examination

Study type

Observational

Funder types

Other

Identifiers

NCT06291454

741100

Details and patient eligibility

About

This study aimed to determine CCL19/MIP3beta(β) and CCL20/MIP3alpha(α) in the gingival crevicular fluid (GCF) of the patients with different periodontitis phenotypes.

A total of 72 individuals, 24 with Stage III Grade B periodontitis (Group 1), 24 with Stage III Grade C periodontitis (Group 2), and 24 periodontally healthy (control group) (Group 3), were included in the study. GCF and clinical periodontal parameters were obtained at baseline. MIP3β and MIP3α levels in GCF were determined by ELISA.

Enrollment

72 patients

Sex

All

Ages

22 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Have at least 20 natural teeth, excluding third molars.
Periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting >30% of the teeth, as detected on clinical and radiographical examinations.
Periodontally healthy control group had no sign of gingival inflammation, no PD > 3mm and no evidence of attachment or bone loss

Exclusion criteria

History of systemic disease.
Regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study.
Periodontal treatment during last 6 months that could affect periodontal status.
Smoking.
History of radiotherapy or chemotherapy.
Current pregnancy, lactation or menopause.