GDM Patients and Serum Amyloid A and Interleukin-1 (IL-1) Receptor Antagonist

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Gestational Diabetes

Treatments: Diagnostic Test: Interleukin-1 (IL-1) receptor antagonist values (A-SAA and IL-1Ra); Diagnostic Test: Serum amyloid A values

Study type: Observational

Funder types: Other

Identifiers

NCT04238936

ATADEK-2020/02

Details and patient eligibility

About

Serum amyloid A and Interleukin-1 (IL-1) receptor antagonist (A-SAA and IL-1Ra) values;

• Comparison of pregnant women with and without GDM diagnosis
• Comparison of insulin therapy and diet-regulated GDM patients
• Comparison of pregnant women with and without LGA (large gestational age)
• Comparison of pregnant women with and without polyhydroamnios
• Investigation of its effect on pregnancy prognosis
• In the prediction of GDM diagnosis, it is aimed to study the sensitivity and specificity of both parameters and cut off values.

(In GDM patients, liver and kidney function parameters will also be evaluated with A-SAA and IL-1Ra levels).

Enrollment: 80 patients

Sex: Female

Ages: 18 to 42 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with 50 gr OGTT + 100 gr OGTT + at 24-28 weeks of gestation
• Patients with 75 gr OGTT + at 24-28 weeks of gestation
• 18-42 years pregnant women

Exclusion criteria

• any infection
• Any known fetal chromosomal or structural anomaly
• Preterm membrane rupture
• Preterm delivery
• Preeclampsia or eclampsia
• Placenta previa

Trial design

80 participants in 2 patient groups

study group ; Patients with gestational diabetes

Description:

Women who are diagnosed with GDM between the ages of 18 and 43 will receive blood in the biochemistry tube. This tube will then be centrifuged. A-SAA and IL-1Ra levels will be checked by ELISA method in serum stored at -80 degrees.

Treatment:

Diagnostic Test: Serum amyloid A values

Diagnostic Test: Interleukin-1 (IL-1) receptor antagonist values (A-SAA and IL-1Ra)

control group ; healthy pregnant women

Description:

Women who are healthy pregnant women, the ages of 18 and 43 will receive blood in the biochemistry tube. This tube will then be centrifuged. A-SAA and IL-1Ra levels will be checked by ELISA method in serum stored at -80 degrees.

Treatment:

Diagnostic Test: Serum amyloid A values