Gender and Opioid Consumption (GenderOpioid)

Mansoura University

Status: Unknown

Conditions: Postoperative; Parotitis

Treatments: Drug: postoperative morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT03006627

GenderOpioids

Details and patient eligibility

About

Opioids are widely used for pain relief after major abdominal surgeries[1]. Sex differences in the opioid analgesia have been reported and investigated in human subjects and animal models In this study, effects of sex difference on response to opioid analgesics after abdominal surgeries will be assessed regarding; analgesic duration (primary variable), frequency of analgesic requirement, total opioid consumption, Opioid related complications (respiratory depression, Nausea & vomiting, itching, over-sedation, delayed intestinal motility).

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I and II Cases scheduled for elective intraabdominal surgeries

Exclusion criteria

• diabetes,
• postmenopausal females,
• laparoscopic surgery,
• regional anesthesia emergency procedures,
• sepsis,
• hepatectomy,
• Renal impairment, and
• hepatic impairment,
• mental and psychiatric disorders.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Male group

Active Comparator group

Description:

All male patients scheduled for upper abdominal surgeries

Treatment:

Drug: postoperative morphine

Female group

Active Comparator group

Description:

All female patients scheduled for upper abdominal surgeries

Treatment:

Drug: postoperative morphine