Gender Differences and SNPs in Asthmatic Patients

University of Catanzaro

Status: Unknown

Conditions: Asthma; Allergic Asthma

Treatments: Other: MicroRNA evaluation; Genetic: genetic evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT04567212

SNPS asthma

Details and patient eligibility

About

The GINA 2020 guidelines suggest that asthma affects approximately 300 million persons worldwide. Even if there is a specific drug treatment for each stage of disease (From mild to severe) in some patients it is not efficacy and it culd be reated to the gender difference Polymorphisms seems to be involved in asthma (allergic or not) even if no data have been published concerning the role of gender in this clinical manifestation. The aim of this study is to assess whether genetic variations involved in the genes encoding the two key leukotriene enzymes, ALOX5 and LTC4S, and CysLTR1 are implicated in the sex difference of allergic asthma in a well-characterized patient cohort.

Full description

The GINA 2020 guidelines suggest that asthma affects approximately 300 million persons worldwide. Even if there is a specific drug treatment for each stage of disease (From mild to severe) in some patients it is not efficacy and it culd be reated to the gender difference Polymorphisms seems to be involved in asthma (allergic or not) even if no data have been published concerning the role of gender in this clinical manifestation. The role of polymorphisms in susceptibility to allergic asthma has been partially investigated but no study has analysed gender subgroups separately, neglecting a their potential predictive role in symptomatological and functional variations in the allergic asthma in both sexes. The aim of this study is to assess whether genetic variations involved in the genes encoding the two key leukotriene enzymes, ALOX5 and LTC4S, and CysLTR1 are implicated in the sex difference of allergic asthma in a well-characterized patient cohort.

Enrollment: 50 estimated patients

Sex: All

Ages: 6 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• asthma (allergic or not) diagnosed according to Global Initiative for Asthma guidelines (GINA 2020).
• signed informed consent

Exclusion criteria

• • infectious diseases

  • neurodegenerative diseases
  • autoimmune diseases
  • neoplasms
  • progressive serious medical conditions (such as cancer, AIDS or end-stage renal disease)
  • alcohol consumption (>3 alcoholic beverages daily)
  • substanceabuse
  • inability to give written informed consent
  • those who will not sign the consent to the processing of personal data

Trial design

50 participants in 2 patient groups

Male-group

Description:

in this group we will enroll only male with asthma

Treatment:

Genetic: genetic evaluation

Other: MicroRNA evaluation

Female-group

Description:

in this group we will enroll only female with asthma

Treatment:

Genetic: genetic evaluation

Other: MicroRNA evaluation