Gender Disparity in Burn Injury Survival

Texas Tech University Health Sciences Center

Status: Terminated

Conditions: Obesity; Burn Injury

Study type: Observational

Funder types: Other

Identifiers

NCT02029768

L14-029

Details and patient eligibility

About

Hypothesis 1: A quantifiable difference in inflammatory cytokines exist in women with burn injury and this correlates with clinical markers of outcome

Hypothesis 2: The amount of adipose tissue contributes to the severity of cellular immune response (CMI) dysregulation in response to burn injury

Skin-fold caliper measurements will be taken on consented patients (both male and female) to determine body fat percentage. Serum samples will be obtained from these patients. The level of inflammatory cytokines in the serum will be measured to determine if there is a link between body fat percentage, pro-inflammatory cytokines and the ability of women to survive burn injury.

Full description

Consented patients admitted to University Medical Center with greater than 15% total body surface area burns will participate in this study. A skin-fold caliper measurement will be performed to determine body fat percentage. Serum samples will be obtained and assayed for inflammatory cytokines to establish whether or not a link between obesity in women and pro-inflammatory cytokines exists. If so, obesity may be a factor which contributes to the gender disparity in burn wound survival.

Enrollment: 42 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men and women ages 18 to 65 years
• Admitted to University Medical Center with greater than 15% total body surface area burns
• Able to provide informed consent or has authorized representative to give informed consent

Exclusion criteria

• Prisoners or pregnant women
• Individuals with injuries that preclude taking caliper measurements

Trial design

42 participants in 2 patient groups

Women with burn injury

Men with burn injury