Gene Analysis in Studying Susceptibility to Wilms Tumor

Children's Oncology Group

Status: Completed

Conditions: Stage II Kidney Wilms Tumor; Stage III Kidney Wilms Tumor; Recurrent Childhood Kidney Neoplasm; Stage IV Kidney Wilms Tumor; Stage I Kidney Wilms Tumor

Treatments: Other: Laboratory Biomarker Analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01808079

AREN09B1

NCI-2013-00120 (Registry Identifier)

Details and patient eligibility

About

This clinical trial studies gene analysis in studying susceptibility to Wilms tumor. Finding genetic markers for Wilms tumor may help identify patients who are at risk of relapse.

Full description

PRIMARY OBJECTIVES:

I. To use a genome-wide association analysis to identify novel genetic variants that confer susceptibility to Wilms tumor.

II. To improve our understanding of the genetic architecture and etiology of Wilms tumor.

III. To facilitate the identification of genetic markers that are associated with an increased risk of developing of Wilms tumor and/or those at risk of aggressive disease, relapse, additional tumors and/or cancer in their offspring.

OUTLINE:

Samples are analyzed for single nucleotide polymorphism (SNP) profiling using real-time polymerase chain reaction (PCR) and multiplex ligation-dependent probe amplification (MLPA).

Enrollment: 1 patient

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• 3000 samples from the 1958 Birth Cohort (58C) and 3000 from the UK Blood Service control series (NBS)

Trial design

1 participants in 1 patient group

Ancillary-correlative (genetic markers of Wilms tumor)

Description:

Samples are analyzed for SNP profiling using real-time PCR and MLPA.

Treatment:

Other: Laboratory Biomarker Analysis