Gene Expression In Pregnancies Complicated by Preeclampsia

University of Rochester

Status

Terminated

Conditions

Preeclampsia

Treatments

Procedure: collection of maternal blood specimen prior to delivery

Procedure: collection of placental tissue

Procedure: collection of strip of decidua from uterine lining from cesarean section deliveries

Procedure: collection of placental cord blood after delivery

Study type

Observational

Funder types

Other

Identifiers

NCT00919360

RSRB# 22086

Details and patient eligibility

About

The purpose of this study is to figure out some of the differences in bodily function between women who have preeclampsia and those who do not.

This may eventually lead to an understanding of its cause. At this time, there is no known way to prevent preeclampsia, and the cause is not known.
The only treatment is delivery of the baby, even if it is premature, in order to decrease the risk to the mother.

Full description

Preeclampsia is a pregnancy-related disorder that occurs in about 6% of all pregnancies.
In its mild for, preeclampsia involves high blood pressure. More severe forms of preeclampsia can lead to more serious pregnancy complications.
At this time, there is no known way to prevent preeclampsia, and the cause is not known. The only treatment is delivery of the baby, even if it is premature, in order to decrease the risk to the mother.
The purpose of this study is to figure out some of the differences in bodily function between women who have preeclampsia and those who do not. This may eventually lead to an understanding of its cause.

Enrollment

125 patients

Sex

Female

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Gravidas at 32-42 weeks gestation,who have preeclampsia as defined by Sibai et al, 1997.
Control patients: Gravidas without history of hypertension of any kind, and matched to cases for parity, gestational age, labor status, maternal age, and race.

Exclusion criteria

Prior betamethasone administration, fetal growth restriction (<3%ile), prior chronic hypertension (nonpregnant or < 20 weeks gestation any pregnancy), chorioamnionitis, major fetal anomaly or chromosome abnormality, multiple gestation, and maternal diabetes (any class except diet-controlled gestational).

Trial design

125 participants in 2 patient groups

Controls

Description:

Gravidas without history of hypertension of any kind, and matched to cases for parity, gestational age, labor status, mode of delivery, maternal age, and race.

Treatment:

Procedure: collection of placental tissue

Procedure: collection of strip of decidua from uterine lining from cesarean section deliveries

Procedure: collection of placental cord blood after delivery

Procedure: collection of maternal blood specimen prior to delivery

Preeclamptics

Description:

Gravidas at 32-42 weeks gestation, delivered by Caesarean Section, who have preeclampsia as defined by Sibai et al, 1997.

Treatment:

Procedure: collection of placental tissue

Procedure: collection of strip of decidua from uterine lining from cesarean section deliveries

Procedure: collection of placental cord blood after delivery