Gene Expression Profiles in Chronic Periodontitis

Kocaeli University

Status: Completed

Conditions: Chronic Periodontitis

Treatments: Genetic: Genom-based whole-genome transcriptomic

Study type: Observational

Funder types: Other

Identifiers

NCT02467283

KOU KAEK 2013 / 15

Details and patient eligibility

About

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

Enrollment: 46 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. CP patients had at least 20 teeth exhibiting >30% of measured sites with >5mm clinical attachment loss.
2. Had bleeding on probing (BOP) at >50% of the proximal sites.

Exclusion criteria

1. Had any known systemic diseases that can influence the periodontal status, oral diseases other than chronic periodontitis and ongoing orthodontic therapy.
2. History of hepatitis, HIV infection, or diabetes; requirement for antibiotic prophylaxis, pregnancy or lactation; and long-term use of anti-inflammatory drugs.
3. Should be free of systemic diseases
4. Individuals had to be older than 18 years of age.

Trial design

46 participants in 2 patient groups

Patients with Chronic Periodontitis

Description:

All subjects were free of systemic diseases and to be included, individuals had to be older than 18 years of age. Chronic periodontitis was diagnosed according to American Academy of Periodontology 1999 Consensus Report.

Treatment:

Genetic: Genom-based whole-genome transcriptomic

Control Patients

Description:

Control subjects had no radiographic evidence of bone loss or any sign of past and present periodontitis. All subjects were free of systemic diseases and to be included, individuals had to be older than 18 years of age.

Treatment:

Genetic: Genom-based whole-genome transcriptomic