Gene Expression Profiles in Predicting Survival of Patients With Head and Neck Cancer

Vanderbilt University Medical Center

Status: Completed

Conditions: Head and Neck Cancer

Treatments: Genetic: microarray analysis; Other: laboratory biomarker analysis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00897052

VU-VICC-HN-0511

VICC HN 0511

VU-VICC-IRB-040509

Details and patient eligibility

About

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict survival of patients with head and neck cancer.

PURPOSE: This laboratory study is assessing gene expression profiles in predicting survival of patients with head and neck cancer.

Full description

OBJECTIVES:

• Identify gene expression profiles associated with survival by DNA microarray assay analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501.

OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray analysis for gene expression profiling.

Enrollment: 29 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of squamous cell carcinoma of the head and neck, including 1 of the following sites:

  • Hypopharynx
  • Larynx
  • Oral cavity
  • Oropharynx

• Stage II-IV disease

• Must have received treatment on clinical trial RTOG-9501

• Formalin-fixed paraffin-embedded tissue samples available

Exclusion criteria

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified