Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers (INDAGA-UK)

Royal Marsden NHS Foundation Trust

Status: Not yet enrolling

Conditions: Salivary Gland Cancer

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT06091878

CCR5899

Details and patient eligibility

About

The INDAGA-UK trial is a retrospective, multi-centre observational study in participants with locally advanced and recurrent salivary gland to investigate t its molecular profiling, and to explore new prognostic and druggable markers. We will analyse samples and data from patients diagnosed with salivary gland cancer from 2013 - 2023. Subject and sample identification will occur over a 12-month period. Samples and data will be analysed over the next 12 months prior to study end.

Enrollment: 250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged over 18
2. Histological diagnosis of salivary gland cancer (SGCs)
3. Availability of archival tissue (acceptable after 2013 up to present)
4. Ability to give informed consent (if applicable)* for retrieving histological specimen and preform molecular analysis *De-identified archival tissue from deceased patients will be collected as part of the study once REC approval is in place, if the patient was alive when the samples were taken and they are not part of the NHS opt out scheme.

Exclusion criteria

1. Different H&N cancer of other histology
2. Thyroid cancers

Trial design

250 participants in 1 patient group

Cohort 1

Treatment:

Other: Observation