Gene Polymorphism of IL17 and IL 23 (COVID 19IL17)

Sohag University

Status: Completed

Conditions: COVID-19 Respiratory Infection

Treatments: Diagnostic Test: laboratory test

Study type: Observational

Funder types: Other

Identifiers

NCT04948515

Soh-Med-21-04-35

Details and patient eligibility

About

rates are in such considerable amount among large population base. The pathogenesis of COVID-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins. These pleiotropic cytokines are secreted at the region of inflammation and released into the circulation by a variety of different cell types, including macrophages, lymphocytes, endothelial cells, epithelial cells during sepsis and acute organ injuries. There has recently found a number of studies reporting that the cytokine storms take part in the course of COVID-19

Full description

Aim Of The Study

1. To evaluate if there is an association between the IL-17, IL-23 gene polymorphism in Patients With COVID 19 by real-time PCR
2. To measure the serum level of IL17 by ELISA in COVID 19 patients by ELISA.
3. To detect if there is an association between gene polymorphism of IL17 and IL23 and severity of a condition in patients with COVID 19 Study design: a cross-sectional study.

The blood samples will be collected from patient records in COVID19 isolation hospitals in sohag governorate and isolation department in sohag university hospitals.

Enrollment: 120 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with Covid19 positive PCR

Exclusion criteria

• Patients with Covid19 clinical criteria not confirmed by PCR

Trial design

120 participants in 2 patient groups

group 1 patients with severe covid 19 respiratory infections

Description:

Patients with severe covid 19 admitted to ICU, blood samples will be collected for testing different genotypes and serum level of IL 17

Treatment:

Diagnostic Test: laboratory test

Diagnostic Test: laboratory test

group 2 patients with non severe covid 19 respiratory infections

Description:

Patients with nonsevere covid 19 admitted to the internal ward, blood samples will be collected for testing different genotypes and serum level of IL 17

Treatment:

Diagnostic Test: laboratory test

Diagnostic Test: laboratory test