Gene x Environment Interplay in Developmental Dyslexia Treatment: A Round-trip Translation Between Humans and Animal (Gedys)

IRCCS Eugenio Medea

Status: Enrolling

Conditions: Reading Disorder

Treatments: Behavioral: Action Video-Game

Study type: Interventional

Funder types: Other

Identifiers

NCT06186882

GR-2021-12375102

Details and patient eligibility

About

Developmental dyslexia affects 7% of school-age children (Male:Female ratio of 1.5:1) and incurs disadvantages in education and occupation. Scientific progress concerning the etiology of developmental dyslexia evidenced the complex gene-environment interaction. The DCDC2-READ1 deletion associates with reading skills and affects the magnocellular-dorsal stream in humans and animals. DCDC2 modifies neural activity within the excitatory pathways. The magnocellular-dorsal stream mediates the function of the attention network. Difficulties in spatial and temporal attention shifting impair letter-to-speech sound integration increasing neural noise. Action video games improve the efficiency of the magnocellular-dorsal stream. The aim of this cutting-edge, round trip translation study is threefold: 1.to unravel new insights behind the pathophysiology of developmental dyslexia, 2. to assess gene-environment interaction effects on developmental dyslexia endophenotypes, and 3. to identify useful clues to foster the identification of new, personalized treatments.

Enrollment: 60 estimated patients

Sex: All

Ages: 5 to 6 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• 5-years old pre-readers,
• normal intelligence quotient,
• no main counter indications for magnetic resonance acquisition,
• no previous diagnosis of any neurodevelopmental disorders.

Exclusion Criteria:

• intelligence quotient below the average range,
• presence of counter indications for magnetic resonance acquisition,
• previous diagnosis of any neurodevelopmental disorders.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

ENVIRONMENTAL STIMULATION

Experimental group

Treatment:

Behavioral: Action Video-Game