General Anesthesia and Autonomic Nervous System in Children (ANESPEDIA)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Anesthesia, General

Treatments: Device: Autonomic nervous system activity

Study type: Observational

Funder types: Other

Identifiers

NCT02714777

2016-A00295-46 (Other Identifier)

1608014

Details and patient eligibility

About

The objective of the ANESPEDIA study is to describe in a pediatric population (aged from 4 to 8 years old) receiving elective surgery, the impact of general anesthesia on autonomic nervous system and their kinetics of early postoperative course (24 hours).

Full description

Some physiological factors such as sport activity or pathological as sepsis, certain chronic diseases or diabetes are known to modulate the overall autonomic activity and the intrinsic capacity of the individual to regulate its sympathovagal balance. These influences can alter the physiological autonomic balance sometimes with positive consequences on the Cardiac frequency-breathing control, blood pressure adjustment depending on the position of the individual, on the status of blood volume, but sometimes deleterious with bad regulation of sinus cardiac activity and respiration rate.

General anesthesia is recognized as one of the factors that can modify more or less sustainable the sympathovagal autonomic balance. While many studies described the effects of anesthesia on the autonomic nervous system, most data are done in adult subjects. For the child who sees intrinsically autonomic physiological changes related to its maturative status, assessment of the impact of anesthesia in the pediatric population in per and postoperative was never realized.

Enrollment: 45 patients

Sex: All

Ages: 4 to 8 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Post-anesthesia Monitoring in pediatric intensive care units or Pediatric Surgery Hospital North of Saint Etienne.
• Compendium of the form signed by the holder of parental authority

Exclusion criteria

• Child with pathologies reaching the central nervous system or the brain stem.
• Children with a severe pathology of cardio-respiratory or heart being referred to treatment.
• Children requiring emergency surgery or trauma or septic or inflammatory context

Trial design

45 participants in 1 patient group

Pediatric population from 4 to 8 years-old

Description:

Description of the Autonomic nervous system activity (parasympathetic activity)

Treatment:

Device: Autonomic nervous system activity