General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer

Changhong Miao

Status: Completed

Conditions: Colorectal Neoplasms

Treatments: Procedure: general anesthesia; Procedure: epidural anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT01978717

08431910200 (Other Grant/Funding Number)

NO.2011-197

Details and patient eligibility

About

The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.

Enrollment: 53 patients

Sex: All

Ages: 51 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with Colorectal Cancer(CRC);
• subjected to the Fast-Track processing of surgery;
• between 18 and 75 years old.

Exclusion criteria

• American Society of Anesthesiologists(ASA) grade > III;
• BMI > 30;
• a history of abdominal surgery, endocrine or immune system dysfunction;
• recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month;
• previous contraindication to epidural anesthesia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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53 participants in 2 patient groups

general anesthesia & epidural anesthesia

Experimental group

Description:

26 patients received general anesthesia combined with epidural anesthesia for surgery, and patient-controlled epidural analgesia for 2 days after surgery

Treatment:

Procedure: general anesthesia

Procedure: epidural anesthesia

general anesthesia

Experimental group

Description:

27 patients received general anesthesia for surgery, and patient-controlled intravenous analgesia for 2 days after surgery

Treatment:

Procedure: general anesthesia