General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery

Clinical Hospital Centre Zagreb

Status: Unknown

Conditions: General Anaesthesia; Muscle Weakness; Rocuronium

Treatments: Drug: Rocuronium; Procedure: General anesthesia for surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT04760912

022

Details and patient eligibility

About

Neuromuscular blocking agents are often used during general anesthesia. Also, general anesthesia may be performed without use of neuromuscular blocking agents.

Avoiding neuromuscular relaxation enables better muscle strength recovery.

Full description

Rocuronium is well used neuromuscular blocking agent during general anesthesia. Although very often used, neuromuscular blocking agents may sometimes have consequence in form of residual neuromuscular block.

Tha aim of the study is to compare influence of rocuronium during general anesthesia on muscle strength recovery measured by hand grip dynamometer. Measuremwnt of hand grip strength is perforrmed before and after general anesthesia. This research should contribute to better choice of anesthesia technique and better quality of patient recovery, as studies so far have not been detaily carried out.

Hypothesis of the research is that anesthesia without use of neuromuscular blocking agents may enable better recovery of muscle strength in immediate postoperative period.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients ASA status I-III for surgery under general anesthesia
• signed informed consent for participating in research

Exclusion criteria

• neuromuscular disease
• poorly controled chronic or acute cardiovascular, respiratory or autoimmune disease
• known allergic reaction to any medication used in this research
• pregnancy
• refusal to participate in this research

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Experimental group general anesthesia without rocuronium

Experimental group

Description:

30 patient ASA classification 1-2 for general anesthesia. Standard anesthesia monitoring. After induction with Propofol and Sufentanil ( doses adjusted according to weight and age) anesthesia was maintained with sevorane. Muscle strength measured on three occasions with Yamar dinamometar for hand grip strength, before induciran to anesthesia and immediate after Salingeru from anesthesia, then again measured in first 24 hours.

Treatment:

Procedure: General anesthesia for surgery

Active comparator: general anesthesia with rocuronium

Active Comparator group

Description:

30 patient ASA classification 1-2 for general anesthesia. Standard anesthesia monitoring with train-of-four (TOF). After induction with Propofol and Sufentanil (doses adjusted according to weight and age) and rocuronium 0,6 mg per kg, anesthesia maintained with sevorane. Muscle strength neasured with Yamar dinamometar for hand grip strength before induction to anesthesia and immediate after awakening from anesthesia, then again measured in first 24 hours.

Treatment:

Procedure: General anesthesia for surgery

Drug: Rocuronium