Generating Health Evidence From Dietary Supplementation With a Micro-vegetable Blend

University of Exeter

Status

Active, not recruiting

Conditions

Inflammation

Treatments

Dietary Supplement: Placebo

Dietary Supplement: Micro-vegetable blend

Study type

Interventional

Funder types

Other

Identifiers

NCT06384690

4331899

Details and patient eligibility

About

Micro-vegetables (MV) are seedlings of larger vegetables. They can be grown quickly and are a concentrated source of micronutrients. MV are thought to have broad health benefits, including many inflammatory conditions. These include metabolic, cardiovascular, and cognitive diseases. This could have important implications for the health of an ageing UK population. Less than a third of British adults consume 5 portions of fruit and vegetables per day; this is the level that reduces risk of morbidity and mortality. Vegetables, including MV may - at least in part - exert their health effects by changing the level and type of bacteria in the mouth and gut. Despite their promise, the MV scientific literature is not yet extensive enough to support definitive health claims. It requires the addition of high-quality studies that are relevant to humans. This study will firstly investigate the anti-inflammatory effects on skeletal muscle and adipose tissue in older adults, using a proteomics approach. Second, this study will assess concentrations of circulating inflammatory markers in the sera collected from participants at baseline and at the conclusion of a 6-week period. Further, this study will describe the effects of six weeks MV consumption on cognition, and the oral and gut microbiome. As the bioactive compounds in the MV are owed to the potential beneficial effects for human health, these will be characterised in sera collected from participants.

Enrollment

32 patients

Sex

All

Ages

60+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Aged 60 years and above
Body mass index > 25kg/m2
Able to give written informed consent to participate in the study

Exclusion criteria

Not meeting any inclusion criteria
Have had an adverse reaction to a local anaesthetic in the past
Hepatitis B, Hepatitis C or HIV positive
Have a bleeding disorder or are regularly taking a medication that will impair their blood's capacity to clot (e.g., aspirin, clopidogrel, warfarin, heparin)
Have had a severe adverse reaction to plasters
Have a gastrointestinal disorder that may impair the absorption of the supplement from the gastrointestinal tract
Have an autoimmune condition
Have a diagnosed neurocognitive disorder
Have a skin condition that is likely to increase the risk of infection at the biopsy site
Frequent use of medication or recreational drugs likely to affect our results
Recent infection or vaccination
Known allergy to any vegetables
Participated in a nutrition supplementation study in the last month