Generation 100: Blood Volume and Cardiac Function in Healthy Aging

Norwegian University of Science and Technology

Status: Completed

Conditions: Ageing

Treatments: Behavioral: high intensity interval training; Behavioral: moderate intensity training

Study type: Interventional

Funder types: Other

Identifiers

NCT01765816

Gen-100-sub1

Details and patient eligibility

About

Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.

As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.

Enrollment: 25 patients

Sex: All

Ages: 70 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ability to walk at least 1km,
• born in 1938,1939,1940,1941 or 1942
• Sufficiently good health to be able to take part in the study, as determined by the researchers

Exclusion criteria

• Illness or disability that precludes exercise or hinders completion of the study
• Uncontrolled hypertension
• Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
• Active cancer
• Test results indicating that study participation is unsafe
• Inclusion in other studies conflicting with participation in this one

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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25 participants in 2 patient groups

high intensity interval training

Experimental group

Description:

one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate

Treatment:

Behavioral: high intensity interval training

Behavioral: moderate intensity training

moderate intensity training

Active Comparator group

Description:

45 minutes of moderate continuous training at 75% of maximal heart rate

Treatment:

Behavioral: high intensity interval training

Behavioral: moderate intensity training