Generation of Cell Banks and Biomarker Isolation From Patients With Amyotrophic Lateral Sclerosis (ALS) (HCD-SLA)

Human Cell Design

Status: Not yet enrolling

Conditions: Amyotrophic Lateral Sclerosis (ALS)

Treatments: Other: sampling blood

Study type: Observational

Funder types: Industry

Identifiers

NCT07099066

2025-A00776-43

Details and patient eligibility

About

The aim of this research is to establish different cell banks from patients with amyotrophic lateral sclerosis (ALS).

Full description

The objective of this research is to:

• Create banks of skin fibroblasts from skin biopsy samples
• Create banks of urine-derived cells (UDCs) from urine samples
• Build a collection of blood samples to enable isolation of biomarkers.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects over 18 years old;
• Subjects who have given their consent and signed an informed, free and express consent form;
• Subjects with diagnosed ALS;
• Subjects affiliated to or benefiting from a social security scheme.

Exclusion criteria

• Subjects with contraindications to the collection of biological samples (blood, skin, urine).
• Subjects undergoing treatment likely to affect hemostasis (anticoagulants, platelet anti-aggregants, etc.) in the month prior to inclusion and during the study;
• Subjects with hereditary or acquired haemostasis disorders;
• Subjects who have undergone physical treatment (radiotherapy, etc.) on the area to be biopsied in the last 6 months;
• Lidocaine-intolerant subjects;
• Subjects who have reached the age of majority and are subject to a protective measure or are unable to express their consent.

Trial design

50 participants in 1 patient group

ALS patients

Treatment:

Other: sampling blood