Generation of Lung Tumor Organoids From Patients Undergoing Diagnostic Bronchoscopy

Regina Elena Cancer Institute

Status: Enrolling

Conditions: Generation of Lung Cancer Organoids

Treatments: Procedure: Biopsies performed via bronchoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT06239584

RS1766/22

Details and patient eligibility

About

Interventional (low intervention level), non-pharmacological, prospective, feasibility pilot study of the preparation of organoids starting from lung tumor tissue collected during biopsies performed via diagnostic bronchoscopy according to standard clinical practice.

Full description

Interventional, non-pharmacological, prospective, feasibility pilot study of the preparation of organoids starting from lung tumor tissue collected during biopsies performed via diagnostic bronchoscopy according to standard clinical practice. This protocol is classified as "interventional" (low intervention level) since that, if possible, an additional quantity of lung tumor tissue will be collected compared to that normally obtained as standard clinical practice, during bronchoscopy, al in order to increase the probability of successful generation of organoids. Involves the prospective recruitment of patients undergoing diagnostic bronchoscopies for suspected lung cancer.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with suspected diagnosis of centrally located and accessible lung cancer endoscopically;
• patients for whom it is indicated to undergo in-depth diagnostic testing through bronchoscopy for the purpose of determining the histotype of the lung neoplasm, according to clinical practice standard;
• aged over 18;
• patients who express informed consent to the study.

Exclusion criteria

• medical contraindication to taking biopsy samples;
• medical contraindication to carrying out endoscopic investigations;
• patients with suspected lung cancer not accessible endoscopically;
• patients with lung neoformation already subjected to diagnostic sampling;
• contraindications to taking an additional quantity of tissue.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Patients undergoing diagnostic bronchoscopies for suspected lung cancer

Other group

Description:

Preparation of organoids starting from lung tumor tissue collected during biopsies performed via diagnostic bronchoscopy according to standard clinical practice

Treatment:

Procedure: Biopsies performed via bronchoscopy