Generation of Organoids of Neuroendocrine Neoplasms of the Gastro-Entero-Pancreatic Tract Obtained From Patients Undergoing Surgery

Regina Elena Cancer Institute

Status: Enrolling

Conditions: Gastro-entero-pancreatic Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT06519500

RS1823/23

Details and patient eligibility

About

Observational, prospective, feasibility pilot study of the preparation of organoids starting from tumor tissue and surrounding healthy tissue, collected during surgery, performed according to standard clinical practice.

Full description

Given the need for the use of experimental models that mimic the tumor of origin

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• over 18 years of age;
• diagnosis of GEP-NEN carried out via histological investigation or via positivity to the uptake PET-CT with 68Ga-peptides;
• availability of adequate material for the preparation of organoid cultures, derived from surgery;
• written informed consent.

Exclusion criteria

• previous chemotherapy treatments

Trial design

40 participants in 1 patient group

Patients undergoing surgery for neuroendocrine neoplasia

Description:

At least 10 cultures of organoids of Gastro-entero-pancreatic neoplasms (GEP-NEN) derived from patients undergoing surgery for neuroendocrine neoplasia. This study will allow us to define the success rate in the generation of organoids from gastro-entero-pancreatic neoplasms (GEP-NEN).