Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis

Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Status: Enrolling

Conditions: Thyroid Diseases; Osteoporosis; Peripheral Neuropathy; Sjogren's Syndrome; Thrombosis; Rheumatoid Arthritis (RA; Amyloidosis; Cardiovascular Diseases; Renal Lesions; RA Complications; Interstitial Lung Disease; Osteoarthritis; Vasculitis; Pulmonary Complications; Liver Disorders

Treatments: Other: Generative AI prediction report for RA complications

Study type: Observational

Funder types: Other

Identifiers

NCT07301892

2025-201-KY

Details and patient eligibility

About

Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases. We are studying how GenAI may affect the diagnosis of various complications of rheumatoid arthritis (RA). In a retrospective study using RA patients' EHR records, we will quantify physician adoption of GenAI predictions for RA complications and co-existing diseases. In a prospective observational study, we will assess the feasibility of using GenAI predictions as additional clinical information to help physicians make more complete diagnoses of RA complications and co-existing diseases, including complex, uncommon, or rare conditions.

Enrollment: 100 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with an initial diagnosis of rheumatoid arthritis (RA).
• All real-world RA inpatients admitted to our department.
• Admission occurring within the real-world data study period.

Exclusion criteria

• Patients subsequently confirmed not to have RA during the study.

Trial design

100 participants in 1 patient group

RA patient group using generative AI prediction reports

Description:

Inpatients newly diagnosed with rheumatoid arthritis in our rheumatology department between October 1, 2025, and June 2026 will be recruited for the study. Physicians will use GenAI predictions of potential RA complications and co-existing diseases, together with confirmatory diagnostic tests, as additional inputs in the differential diagnosis process.

Treatment:

Other: Generative AI prediction report for RA complications