Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors (FAS)

Laval University

Status

Active, not recruiting

Conditions

Cardiovascular Disease

Treatments

Dietary Supplement: n-3 PUFA supplementation

Study type

Interventional

Funder types

Other

Identifiers

NCT01343342

FAS

Details and patient eligibility

About

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors.

Full description

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors. To do so, the metabolic risk factor response to an n-e PUFA supplementation will be compared in carriers and non-carriers of polymorphism within genes acting as fatty acids sensors.

Enrollment

200 estimated patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

healthy men and women aged between 18 to 50 years;
having a BMI between 25 and 40kg/m2;
plasma triglycerides levels <4.0 mmol/L;
non-smokers;
free of any thyroid or metabolic disorders requiring treatment such as diabetes, hypertension, severe dyslipidemia, and coronary heart disease.

Exclusion criteria

subjects taking medication for hyperlipidemia, hypertension, diabetes or taking anticoagulant or n-3 PUFA supplementation;
having a taste aversion for fish, fish allergy or regular alcohol drinker;
body mass index > 40kg/m2;
pregnant or nursing women.