Genetic Analysis of Pediatric Psoriasis

Northwestern University

Status: Completed

Conditions: Psoriasis

Treatments: Other: Saliva or buccal sample

Study type: Observational

Funder types: Other

Identifiers

NCT03768284

2018-2259

Details and patient eligibility

About

This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members. Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.

Enrollment: 86 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent.
• Parents of patients who developed psoriasis before 12 years of age
• Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated.

Exclusion criteria

• Patients, parents, and other family member unable to give a saliva or buccal swab sample.
• Patients, parents, and other family member unable to give written informed consent.

Trial design

86 participants in 3 patient groups

Psoriasis patients

Description:

Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent.

Treatment:

Other: Saliva or buccal sample

Parents of psoriasis patients

Description:

Parents of patients who developed psoriasis before 12 years of age

Treatment:

Other: Saliva or buccal sample

Up to third-degree family members with or without psoriasis

Description:

Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated.

Treatment:

Other: Saliva or buccal sample