Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

University of Leipzig

Status: Unknown

Conditions: Coronary Arteriosclerosis; Genetic Predisposition to Disease; Biological Markers; Atherosclerosis; Carotid Artery Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT00497887

276-2005

Details and patient eligibility

About

Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.

Enrollment: 4,000 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients assigned to coronary angiography

Exclusion criteria

• Cancer
• Acute myocardial infarction
• Inability to give informed consent