Genetic and Epigenetic Mechanisms Underlying Cocoa Health Benefits

Nestlé

Status: Completed

Conditions: Healthy

Treatments: Other: Cocoa Pure; Other: Placebo

Study type: Interventional

Funder types: Industry

Identifiers

NCT02292576

11.21.NRC

Details and patient eligibility

About

Evaluate if gene expression changes in SOD2 explain the health benefits of high polyphenols cocoa

Full description

Evaluate if gene expression changes in SOD2 explain the health benefits of high polyphenols cocoa.

Enrollment: 50 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults
• BMI between 18.5 and 30 kg/m2
• Sedentary to moderate physical activity habits

Exclusion criteria

• Consumption of dietary supplements, antioxidants or anti-inflammatory medication, such as aspirin, ibuprofen, naproxen, or any medication that can affect the study outcomes
• Actively smoking
• Suspected abuse of alcohol or illicit drugs
• Significant illness within two weeks prior to study start or any active systemic infection or medical condition that may require treatment or therapeutic intervention during the study
• Subject who cannot be expected to comply with study procedures
• Currently participating or having participated in another clinical trial during last 4 weeks prior to the beginning of this study
• Consumption of chocolate or its derivates 24 hours before the blood sample taken

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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50 participants in 2 patient groups

Acute dose/Chronic dose

Experimental group

Description:

Acute dose/Chronic dose.

Treatment:

Other: Cocoa Pure

Other: Placebo

Chronic dose/Acute dose

Experimental group

Description:

Chronic dose/Acute dose.

Treatment:

Other: Cocoa Pure

Other: Placebo