Genetic and Molecular Characteristics of Mexican Adults With Acute Myeloid Leukemia: a Prospective Multicentric Study.

Mexican Agrupation for Hematology Study

Status: Not yet enrolling

Conditions: Acute Myeloid Leukemia

Treatments: Diagnostic Test: Molecular panel

Study type: Observational

Funder types: Other

Identifiers

NCT04311060

HEM-3094-19-25-1

Details and patient eligibility

About

Newly diagnosed adults patients with Acute Myeloid Leukemia will be assessed as traditionally by the treating institution using classic clinical, demographic and cytogenetic variables. Complementary molecular tests will be performed in the patients included in the study using PCR to detect classic CBF (Core Binding Factor) rearrangements: CBFB-MYH11 [inv(16)(p13;q22), isoforms A, E and D; AML-ETO (RUNX1-RUNX1T1) (t8;21)(q22;q22). NGS (Next Generation Sequencing) to detect mutations in: FLT3-ITD and TKD, NPM1, CEBPA, RUNX1, TP53, ASXL1, IDH1, IDH2 and KIT

Enrollment: 100 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newly diagnosed AML
• Over 15 years of age
• Flow cytometry confirmation
• Candidate for treatment (intensive or not intensive)

Exclusion criteria

• Acute Promyelocytic Leukemia
• Mixed phenotype leukemias
• Isolated myeloid sarcoma
• Blastic plasmacytoid dendritic cell neoplasm