Genetic and Phenotypic Characteristics of Mitral Valve Prolapse (MVP)

Nantes University Hospital (NUH)

Status: Unknown

Conditions: Genetic Disease; Mitral Valve Prolapse

Study type: Observational

Funder types: Other

Identifiers

NCT03884426

RC12_0143

Details and patient eligibility

About

Phenotypic characterisation of MVP by echocardiography in families. Identification of genes involved in MVP.

Full description

After clinical identification of patients with MVP, doctors organize 1st degree relative familial screening. A comprehensive echocardiography was carried out along with clinical examination. All echo data were stored for off-line analysis by a sonographer in our Core-lab. Blood was sample at the time of echocardiography in adult patients for DNA analyses. Follow-up for mitral valve changes will be performed after 5 years.

Enrollment: 1,000 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients of any age
• with typical mitral valve prolapse
• relatives examined during familial screening

Exclusion criteria

• Refusal of the patient

Trial design

1,000 participants in 2 patient groups

Patients with MVP

Description:

The patients concerned are patients with known or recently discovered Barlow-type mitral prolapse, whatever the degree of severity.

Normal relatives

Description:

Related healthy patients, for an average of 6 individuals per family