Genetic Aortic Diseases and Cardiovascular Complications. An Observational Survey of Risk Factors. (PROM-1)

San Donato Group (GSD)

Status: Enrolling

Conditions: Thoracic Aortic Aneurysm (TAA)

Treatments: Other: Journey to diagnosis; Other: Awareness and self-esteem, acceptance of the condition; Other: Quality of life, functional health and well-being; Other: psychological and physical well-being

Study type: Observational

Funder types: Other

Identifiers

NCT07391293

PROM-1

Details and patient eligibility

About

The aim of this observational study is to define the behavioural and cardiovascular risk factor profiles of patients with genetic aortopathies. The main questions it aims to answer are:

• How do the interconnections between lifestyle, stress, psychological condition, perception of illness, and state of health influence each other in this population?
• Beyond traditional risk factors, additional emerging factors should be considered, including pregnancy-related complications, sedentary lifestyle, early menopause and depression. The interplay between eating disorders, lifestyle factors and autoimmune or inflammatory bowel diseases remains poorly understood.

Full description

Thoracic aortic aneurysms (TAA) present peculiar symptoms as well as high mortality due to complications related to dilatation and dissection of the ascending aorta and great arteries. The presence or absence of extra-aortic features determines whether TAADs are syndromic, associated with diseases affecting other systems and organs, or non-syndromic, with manifestations limited to the aorta. Life expectancy of patients withTAA has improved markedly in the last decades, but still remains lower than that of the general population.

Enrollment: 208 estimated patients

Sex: All

Ages: 14 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• signed onformed consent
• Ability to speak, read and write in Italian

Exclusion criteria

-

Trial design

208 participants in 1 patient group

TAA

Description:

subjects with TAA aged between 14 and 60 years

Treatment:

Other: psychological and physical well-being

Other: Awareness and self-esteem, acceptance of the condition

Other: Quality of life, functional health and well-being

Other: Journey to diagnosis