Genetic Biomarkers in Tissue Samples From Patients With Osteosarcoma

Children's Oncology Group

Status: Completed

Conditions: Osteosarcoma

Treatments: Other: laboratory biomarker analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01807143

AOST10B1

NCI-2013-00124 (Registry Identifier)

Details and patient eligibility

About

This clinical trial studies genetic biomarkers in tissue samples from patients with osteosarcoma. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer

Full description

Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Tissue Study Population Description: Samples from the COG Sampling Method: Non-Probability Sample

PRIMARY OBJECTIVES:

I. To use PET sequencing to analyze DNA from ten human primary osteosarcoma samples, along with matched normal tissue where available.

OUTLINE:

Tissue samples are analyzed for translocations and deletions and analyzed using polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH).

Enrollment: 10 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Samples from the COG tissue repository

Trial design

10 participants in 1 patient group

Correlative studies

Description:

Tissue samples are analyzed for translocations and deletions and analyzed using PCR or FISH.

Treatment:

Other: laboratory biomarker analysis