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Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure

Beth Israel Lahey Health logo

Beth Israel Lahey Health

Status

Active, not recruiting

Conditions

Kidney Failure
Unexplained Proteinuria
End Stage Renal Disease
Focal Segmental Glomerulosclerosis
Nephrotic Syndrome

Study type

Observational

Funder types

Other
Other U.S. Federal agency
NIH

Identifiers

NCT02194582
5R01DK054931-18 (U.S. NIH Grant/Contract)
2009P000430

Details and patient eligibility

About

The investigators are trying to learn more about the cause of kidney diseases such as Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic syndrome by studying genetics. The investigators are interested in discovering which genes play a role in causing a predisposition to FSGS/NS. The investigators also want to learn why FSGS/NS can run in families. Participation in our study involves a saliva sample and a urine sample that you can give from home. There is no cost to participate. All information is kept private and confidential. The investigators also like to include healthy volunteers (parents, spouses) if interested/available but of course this is completely optional.

Full description

The investigators welcome anyone (with or without a family history) with unexplained, non syndromic FSGS, nephrotic syndrome, or proteinuria to join the study. Participation involves a saliva (or blood if it is preferable) sample and urine sample (if applicable). There is no cost to participate and the study can be done from home in most cases.

Enrollment

2,050 estimated patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Subjects with FSGS (focal segmental glomerulosclerosis)
  • Subjects with NS (nephrotic syndrome)
  • Subjects with unexplained kidney failure (have had a transplant or on dialysis)
  • Subjects with unexplained proteinuria
  • Family members of a person with FSGS, NS, kidney failure, or unexplained protein in their urine
  • Healthy volunteers

Exclusion criteria

  • Patients whose kidney disease is already explained by another syndrome such as (Branchio Oto Renal Syndrome or Alports syndrome)
  • Patients who already know the genetic cause of their kidney disease

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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