Genetic Determinant of Blood Pressure Sensitivity to Salt Intake (JEU004)

Assistance Publique - Hôpitaux de Paris

Status: Terminated

Conditions: Hypertension

Treatments: Other: Diet Amiloride

Study type: Interventional

Funder types: Other

Identifiers

NCT01706887

P060215

Details and patient eligibility

About

Nedd4.2 is a regulator of ENac, a transporter of sodium involved in the regulation of salt retention by the kidney. The study address the consequence of a frequent genetic variation leading expected to impact the function of Nedd4 and in turn, the ability of kidneys to excrete salt intake. Our hypothesis is that the genetic variants of Nedd4.2 could constitute a genetic predisposition to (or protection against) salt-sensitive hypertension.

Full description

Subjects were submitted one week to a low sodium-high potassium diet, and then switch to a high sodium,-low potassium diet for two weeks. the last week, subject were taken a 20 MG daily dose of amiloride, a potassium sparing diuretic.

Enrollment: 219 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• healthy volunteers
• between 18 and 35 years odl
• BMI between 18 and 28 Kg per m2
• non smokers
• no active disease
• no alcool or drug abuse

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

219 participants in 1 patient group

Diet Amiloride

Experimental group

Description:

One week Low Na diet (10 mmol/d) followed by ine week high Na diet (200 mmol/d) followed by 2 weeks administration of amiloride (10 mg the 1 st week and the 20mg).

Treatment:

Other: Diet Amiloride