Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)

Lille University

Status

Enrolling

Conditions

Healthy

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT06740136

2022-A01308-35 (Other Identifier)

2022-007

Details and patient eligibility

About

The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.

Full description

Elite-level sports expose athletes to training loads designed to induce muscle damage, aiming to achieve optimal physiological adaptations. However, the repetitive nature of such damage increases the risk of injury. The ability to assess an athlete's susceptibility to fragility is therefore crucial for optimizing their training and performance. Genetic factors appear to play a significant role in the occurrence of these injuries, particularly through subtle variations in DNA sequences. Depending on the location of these variations within a gene, they may or may not alter the expression or function of the associated protein. The investigators aimed to investigate the relationship between genetic polymorphisms and biological parameters in the context of exercise-induced muscle damage.

Enrollment

300 estimated patients

Sex

All

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male or female
Aged between 18 and 35
Weighing more than 50 kg
Member of a sports club affiliated to an Olympic federation
Socially insured
Willing to comply with all study procedures and duration of the study

Exclusion criteria

Medical history contraindicating sporting activities
Current medical treatment
Not a member of a sports club affiliated to an Olympic federation
Administrative reasons: impossibility of receiving informed information, impossibility of participating in the entire study, absence of social security coverage, refusal to sign consent form.