ClinicalTrials.Veeva

Menu

Genetic Determinants of Warfarin Anticoagulation Effect

H

Hadassah Medical Center

Status

Unknown

Conditions

Pulmonary Embolism
Atrial Fibrillation
Venous Thrombosis

Treatments

Drug: Warfarin

Study type

Interventional

Funder types

Other

Identifiers

NCT00162435
yc19553-HMO-CTIL

Details and patient eligibility

About

The response to warfarin varies greatly among individuals. Some of this variability can be ascribed to genetic polymorphisms in the gene encoding for CYP2C9, the enzyme mediating the metabolism of S warfarin. In addition genetic polymorphism in other genes (i.e. VKORC1, factor VII) have been shown to account for some of the variability in the response to warfarin irrespective of CYP2C9.The present study has several segments:

  1. Evaluation of the relationship between genetic polymorphisms in the genes encoding for CYP2C9, VKORC1 and factor VII and warfarin maintenance dose at steady state. This study is a confirmation of previous data in our own population.
  2. Evaluation of relationship between genetic polymorphisms in the genes encoding for CYP2C9, VKORC1 and factor VII and warfarin loading dose during the induction period.
  3. Testing the hypothesis that warfarin loading based on the individual's combined CYP2C9, VKORC1 and factor VII genotype may be more efficient and associated with reduced adverse drug effects.

Enrollment

500 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients in whom warfarin is about to be initiated
  • Desired therapeutic range >2 and <3

Exclusion criteria

  • Refusal to participate in the study

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

500 participants in 2 patient groups

Genetic
Experimental group
Treatment:
Drug: Warfarin
Control
Experimental group
Treatment:
Drug: Warfarin

Trial contacts and locations

1

Loading...

Central trial contact

Yoseph Caraco, MD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems