Genetic, Environment and Its Interaction Analysis for Cardiovascular Autonomic Neuropathy

Tongji University

Status: Completed

Conditions: Cardiovascular Autonomic Neuropathy

Treatments: Other: not intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02461342

CANGEI_Dr.Tang

Details and patient eligibility

About

A large-scale, community-based, cross-sectional study was conducted to explore the extent to which genetic, environment and its interactions associated with cardiovascular autonomic neuropathy (CAN) in general Chinese population. A total of more than 2000 participants were recruited by using multiple stages sampling (first cluster sampling and then simply sampling). Data involved in variables of genetic, environment were collected. Every participants was complete DNA extracted and genotyped by using single nucleotide polymorphism (SNP). Cardiovascular autonomic functions were measured by using short-term heart rate variability (HRV) to evaluate the outcome of CAN. Genetic analysis were employed to evaluate genetic variants, environmental risk factors and its interactions for CAN.

Full description

A large-scale, community-based, cross-sectional study was conducted to explore the extent to which genetic, environment and its interactions associated with cardiovascular autonomic neuropathy (CAN) in general Chinese population. A total of more than 2000 participants were recruited by using multiple stages sampling (first cluster sampling and then simply sampling). Data involved in variables of genetic, environment were collected. Every participant was complete DNA extracted and genotyped by using single nucleotide polymorphism (SNP). Cardiovascular autonomic functions were measured by using short-term heart rate variability (HRV) to evaluate the outcome of CAN. Genetic analysis were employed to evaluate genetic variants, environmental risk factors and its interactions for CAN.Univariate and multiple variables analysis have been performed to examine potential environmental and genetic risk factors of CAN.

Enrollment: 2,100 patients

Sex: All

Ages: 30 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Survey Chinese participants with undiagnosed CAN Aged 30-90 years, were included in this study.

Exclusion criteria

Some subjects were excluded from the study to eliminate potential confounding factors that may have influenced their CA function. Briefly, the exclusion criteria were as follows:

1. history or findings of arrhythmia and hyperthyroidism or hypothyroidism
2. pregnancy or lactation
3. serious hepatic or renal dysfunctions (GFR < 30 mL/min/1.73m2). Of these subjects, complete baseline data were obtained for 2,092 (69.46%) of the participants.

Trial design

2,100 participants in 1 patient group

Dr.Tang's research group

Description:

Dr.Tang's research group for genetic, environment and its interaction analysis of human complex disease

Treatment:

Other: not intervention