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Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)

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Mayo Clinic

Status

Active, not recruiting

Conditions

Primary Biliary Cirrhosis

Treatments

Genetic: Genetic Analysis

Study type

Observational

Funder types

Other

Identifiers

NCT01161953
670-02 PBC

Details and patient eligibility

About

Primary Biliary Cirrhosis (PBC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC.

This study is being done to investigate whether genes make people more likely to develop PBC. Discovery of these proposed genes will help us better understand how PBC developes, and subsequently, to apply new approaches for its prevention, diagnosis and treatment.

Enrollment

1,500 estimated patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Men and women between the ages of 18-90 who have a history of PBC.
  • PBC patients who have undergone a liver transplant are eligible.
  • Family members (1st degree relatives) of enrolled PBC patients are eligible.

Exclusion criteria

  • Individuals with no history of PBC or those unable to provide consent.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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