Genetic Etiology in Premature Ovarian Insufficiency (POI)

BEGUM AYDOGAN

Status: Completed

Conditions: Genetic Predisposition to Disease; Primary Ovarian Insufficiency

Study type: Observational

Funder types: Other

Identifiers

NCT01973075

22547

Details and patient eligibility

About

Premature Ovarian Insufficiency (POI), first described by Albright in 1942, is defined as an increase in Follicle Stimulating Hormone (FSH), an insufficiency of the ovarian function leading to an early menopause (<40 years of age).Today, only 35% of POI's etiology can be explained. Causes enlightening POI may be enumerated as follows, according to their frequency: genetic mutations, autoimmune defects and abnormalities detected on the X chromosome.The purpose of the study is to determine the frequency of the genetic abnormalities and polymorphisms described above in the POI Turkish population

Enrollment: 100 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosed premature ovarian failure patients
• 20-40 years old female patients

Exclusion criteria

• Surgical surgical menopause
• Female patients who can't meet the age range criteria

Trial design

100 participants in 2 patient groups

premature ovarian Insufficiency

Description:

4ml whole blood sample is going to collect from premature ovarian Insufficiency group for the assessment of genetic abnormalities

healthy control group

Description:

4 ml of whole blood is going to taken from healthy control group