Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis

Yonsei University

Status: Completed

Conditions: Papillary Thyroid Microcarcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT01384669

4-2011-0212

Details and patient eligibility

About

In this study, the investigators look at the genetic expressional alteration which influenced on the early lateral neck node metastasis in thyroid papillary microcarcinoma.

Full description

Papillary thyroid carcinomas (PTCs) measuring 1.0 cm or less in diameter were defined as papillary thyroid microcarcinomas (PTMCs) by the World Health Organization (WHO), emphasizing on their benign behavior, probably of little clinical significance, which do not affect patients' survival. However, some reported that PTMCs may have aggressive behavior, can cause locoregional recurrences, cervical lymph node metastases, and even distant metastases. But till now, the characteristics of PTMCs with early lateral neck node metastasis were only reviewed and described by the clinicopathological parameters, and no analysis of PTMCs by the gene level is available. In these study, we investigate the genetic expressional alteration which influenced on the early lateral neck node metastasis in thyroid papillary microcarcinoma.

Enrollment: 29 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age≥20 years old
• Conventional type papillary thyroid microcarcinoma (0.5cm≤tumor size≤1.0cm)
• group 1: no lymph node metastasis /group 2: with lateral neck node metastasis

Exclusion criteria

• tumor with capsular invasion (T3 tumor)
• distant metastasis
• combined underlying thyroiditis

Trial design

29 participants in 2 patient groups

Group 1

Description:

papillary thyroid microcarcinoma without lymph node metastasis

Group 2

Description:

papillary thyroid microcarcinoma with lateral lymph node metastasis