Genetic Influences on Statin Blood Concentrations in African Americans

The Ohio State University

Status: Completed

Conditions: Hyperlipidemia; Hypercholesterolemia; Dyslipidemia

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01569867

K23GM100372 (U.S. NIH Grant/Contract)

OSU 2011H0402

R01MD011307 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study intends to determine the effects of genetic polymorphisms on statin response and daily systemic exposure (24-hour area under the time-concentration curve) of statins in African-American patients.

Enrollment: 501 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• African-American patients taking a statin metabolized by CYP3A (e.g., atorvastatin, simvastatin, or lovastatin)

Exclusion criteria

• Age less than 18 years

Trial design

501 participants in 1 patient group

statin