Genetic Markers of Diabetic Ulcers and Personalized Treatment Targets Research

The First Affiliated Hospital of University of South China

Status: Enrolling

Conditions: Diabetic Ulcers

Study type: Observational

Funder types: Other

Identifiers

NCT06979037

NHFY20240506

Details and patient eligibility

About

This clinical trial involves collecting peripheral blood, ulcer tissue, and fecal samples from diabetic ulcer patients for bioinformatics analysis to screen genetic markers significantly associated with ulcer risk and healing differences. Furthermore, multi-omics data will be integrated to establish a diabetic ulcer risk prediction model. Based on key single nucleotide polymorphisms and their regulatory pathways, potential new drug targets for promoting healing will be explored, providing a genetic basis for personalized treatment.

Enrollment: 712 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Subjects who voluntarily participate in this clinical study and sign informed consent;
• 2. Patients with type 2 diabetes and diabetic ulcers;
• 3. Disease duration ≥ 10 years or age ≥ 55 years at enrollment;
• 4. Inpatient or outpatient who can be monitored by the same investigating team throughout the duration of the study.

Exclusion criteria

• 1. Severe vascular occlusion or impairment;
• 2. Patients with congenital heart disease, aortic dissection, or other severe cardiovascular diseases;
• 3. Patients with ulcers caused by factors other than diabetes;
• 4. Patients with severe liver and kidney dysfunction or serious neurological impairment.