Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study

Mass General Brigham

Status: Withdrawn

Conditions: Hypertension

Treatments: Drug: Lisinopril, Atenolol

Study type: Interventional

Funder types: Other

Identifiers

NCT01009944

2007p002290

Details and patient eligibility

About

The purpose of this study is to develop an approach to provide personalized medicine to individuals who have hypertension (high blood pressure). The investigators plan to use people's genetic characteristics (traits) to determine what medication they should use to lower their blood pressure most effectively. The investigators will give individuals one of two medications to treat hypertension (lisinopril or atenolol). The investigators believe that depending on the individuals genetic background one medication will work better in lowering their blood pressure.

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and female hypertensive participants who were previously studied in SCOR program.

Exclusion criteria

• Diabetes
• Taking other medications beside thyroid or estrogen supplements.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Lisinopril, Atenolol

Experimental group

Treatment:

Drug: Lisinopril, Atenolol