Genetic Mutation in Recurrent Cervical Cancer

Lei Li

Status: Unknown

Conditions: Microsatellite Instability; Genomic Structural Variation; Copy Number Variation; Nucleotide Variant; PD-L1; Recurrent Cervical Cancer; Insertion-deletion Variation; PD-1; Total Mutation Burden

Treatments: Diagnostic Test: Multi-gene panel testing

Study type: Observational

Funder types: Other

Identifiers

NCT04191226

CC-TMB

Details and patient eligibility

About

Little is known about the characteristics of genetic mutation in recurrent cervical cancer. This study is to explore the targeted genetic mutations via a multi-gene panel, which consists of more than 500 hundred genes. The mutation characteristics are to be revealed in single nucleotide variants, copy number variations, insertion-deletion variations, and genomic structural variations. The total mutation burden (TMB) will be calculated. The status of microsatellite instability, expression of PD-1 and PD-L1 antibodies are also tested. These findings will be studies in association with the patients' prognosis and sensitivity to platinum-based chemotherapy and immunotherapy.

Enrollment: 300 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18 years or older
• Pathology confirmed of recurrent cervical adenocarcinoma, squamous carcinoma or adenosquamous carcinoma
• With available materials for analysis
• With detailed clinicopathological information
• Given consent to participate the trial

Exclusion criteria

• Not meeting all of the inclusion criteria