Genetic Polymorphism and Post Operative Nausea and Vomiting (PONV) (ponv)

Instituto do Cancer do Estado de São Paulo

Status: Completed

Conditions: Polymorphism, Genetic; Genetic Predisposition to Disease; Postoperative Nausea

Treatments: Diagnostic Test: DNA extraction

Study type: Observational

Funder types: Other

Identifiers

NCT03627780

NP1127/2017

Details and patient eligibility

About

Nausea and vomiting affects 25-30% of individuals in the post-operative period and can reach more than 70-80% in high-risk patients. inherited factors may play a significant role in individual susceptibility and clinical research on hereditary factors involved in the pathogenesis of Postoperative nausea and vomiting (PONV) and chemotherapy nausea and vomiting (CINV) is relatively new. The aim of this study is to investigate whether inter-individual differences related to PONV are associated with genetic factors. 300 patients will be evaluated in postoperative oncological surgeries. The peripheral leukocyte DNA will be extracted by the Salting Out Procedure method and processed to genotyping for 48 SNPs from 15 candidate genes by real-time PCR by the Taqman method. The possible associations with demographic data and factors related to surgery will be analyzed by univariate and multivariate analysis.

Full description

The aim of this study is to investigate whether inter-individual differences related to PONV are associated with genetic factors. 300 patients will be evaluated in postoperative oncological surgeries. The peripheral leukocyte DNA will be extracted by the Salting Out Procedure method and processed to genotyping for 48 single nucleotide polymorphisms (SNPs) from 15 candidate genes by real-time PCR by the Taqman method. The possible associations with demographic data and factors related to surgery will be analyzed by univariate and multivariate analysis.

Enrollment: 300 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• High and intermediate-risk patients for PONV (Apfel score 2, 3 and 4)

Exclusion criteria

• Low risk patients for PONV (Apfel score 0 and 1)

Trial design

300 participants in 2 patient groups

PONV

Description:

Patients presenting with postoperative nausea and vomiting

Treatment:

Diagnostic Test: DNA extraction

no PONV

Description:

Patients not presenting with postoperative nausea and vomiting

Treatment:

Diagnostic Test: DNA extraction