Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease

Kaohsiung Medical University

Status: Unknown

Conditions: Chronic Liver Disease; Hepatitis C Virus Infection

Treatments: Genetic: TNF-alpha and IL-10

Study type: Interventional

Funder types: Other

Identifiers

NCT00630006

KMUH-IRB-950182

Details and patient eligibility

About

The prognosis of chronic hepatitis C virus (HCV)infeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity. It is known that cytokine gene (including tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) polymorphism affect disease prognosis.This study aims to assess the effect of TNF-alpha and IL-10, and their interaction,on prognosis of HCV-related chronic liver disease

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Anti-HCV-positive patients

Exclusion criteria

• Anti-HCV-negative patients