Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma

Kaohsiung Medical University

Status: Completed

Conditions: Chronic Liver Disease; Hepatocellular Carcinoma; Hepatitis B

Treatments: Genetic: Polymorphism of IL-1 beta and TNF-alpha

Study type: Interventional

Funder types: Other

Identifiers

NCT00629486

KMUH-IRB-950181

Details and patient eligibility

About

By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.

Full description

Hepatitis B virus (HBV)infection is the major risk factor for chronic liver disease and hepatocellular carcinoma (HCC). Host immunogenetic factors contribute to HBV-associated liver damage and/or carcinogenesis. Variant cytokine alleles, including tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β), might contribute to interindividual difference in inflammatory responses and account for heterogeneous disease outcome of infectious disease.

By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.

Enrollment: 300 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• HBsAg-positive patients

Exclusion criteria

• HBsAg-negative patients

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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300 participants in 1 patient group

cytokines were determined

Experimental group

Description:

prevalence of genetic polymorphisms of interleukin 1B was measured in HBV-related hepatocellular carcinoma

Treatment:

Genetic: Polymorphism of IL-1 beta and TNF-alpha